The main causes for breakdown for long running times are the piezoceramic of the actuators and clogging of the fluidic path. Clogging can be avoided by filtering. The piezoceramic can be damaged by recurring voltage/current-spikes. So if the switch-on and switch-off action is done properly, i.e. without any voltage/current-spikes of the driving signal, the actuator will survive. If not, the piezoceramic will be damaged and the performance of the micropump will decrease.