Droplet generation

droplet generation on a chip

In microfluidics, droplet generation is an important but very complicated topic. The goal is to create droplets of a specific size depending on the application. Droplet generation in microfluidics is based on the use of two immiscible phases. These two are:

  • the continuous phase (oil, medium in which droplets flow) and
  • the dispersed phase (water, the droplet).

For generating droplets, microfluidic systems generally include a microfluidic chip, a fluid handling system and tubing. You can then connect this system to a computer and a microscope to visualize the droplet formation.

By now, droplet-based microfluidic systems have found their way into laboratories. Now, it is possible to generate (monodisperse) droplets in the femto- to nanoliter scale. So, they opened up unlimited experimental possibilities. For example, digital PCR and single cell experiments where the compartmentalization and surface-to-volume ratio are important.

Case Study: Facilitating droplet generation with the mp6 micropump

Sketched structure of an application for droplet generation

This case study shows how droplet generation is possible. We are using the mp6 micropump with a pressure sensor, reagents, fluidic accessories and a Droplet Generator Chip obtained from our partner microfluidic ChipShop.

The graphic on the left shows you how the system in the case study is set up. To ensure optimal performance, there are some crucial information you need to consider. Learn more about how you can generate droplets with our mp6 micropump here:

Our case study gives you an in-depth view into the workings of this great use for microfluidics. If you want to learn more about the chips in our portfolio, continue reading about microfluidic chips.

Video: Setting up a system for droplet generation

Droplet generation is an important topic in medical technology. This technology is especially interesting in single cell analysis and sorting. In this video, we are able to build a small and flexible system that does not need a compressed air line like many other systems. For this, we use the mp6 micropump and a chip by our partner microfluidic ChipShop.

Check out the video and learn more about droplet generation:


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Then take a look at our other case studies. Or browse our video selection on our YouTube channel. Both give you a more in-depth view into the microfluidic technologies we develop and use.