Case Study: Measuring cell density in a microfluidic system utilizing optical density

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Microfluidic systems become more and more important in biotechnological applications in the pharma, cosmetics and food & beverage markets due to its small footprint. Therefore, these systems are an easy option for parallelization, modularity and scalability as well as low power and reagent consumption.

Culturing cells is a highly sensitive procedure. Some important parameters need to be monitored closely and accurately, i.e. temperature, dissolved oxygen, CO2, pH, concentration of feed, VOC and cell density.

The cell density is often measured by an optical measuring principle taking the optical density (OD) value generated by turbidity in the cell suspension and its potential for transmitting respectively absorbing light.

This case study shall share the idea of a cost-efficient, microfluidic setup for microbioreactors in cell culturing processes taking the OD and monitoring the cell growth.

Read the full Case Study here: Measuring cell density in a microfluidic system